Hello, Wisconsin! It's 1995 and Kitty and Red Forman welcome a new generation of teenagers into their basement when their granddaughter Leia decides to spend her summer in Wisconsin. Sex, drugs and rock 'n roll never dies, it just changes clothes.

Being a pro athlete didn't pan out for Colt. Now he's helping his dad and brother keep the ranch afloat, and figuring out how he fits into the family.

Set in the Wisconsin suburbs of the United States, Eric Forman lives under the authority of his parents, Red and Kitty. Next door is his girlfriend/neighbor, Donna Pinciotti and her parents Bob and Midge. The rest of the gang includes Jackie, and her sometimes boyfriend, Kelso, Hyde, a conspiracy theorist and Fez, a foreign exchange student. The gang mostly likes to spend their time in Eric's basement, pondering their lives, parents, and their futures, while getting into many funny mishaps and adventures in their teenage lives along the way.

Charlie is a well-to-do bachelor with a house at the beach, a Jaguar in the front, and an easy way with women. His casual Malibu lifestyle is interrupted when his tightly wound brother Alan, who's facing a divorce, and his son Jake, come to live with him. Together, these two and a half men confront the challenges of growing up; finally. Complicating matters are the brothers' self-obsessed, controlling mother, Evelyn, Alan's estranged wife, Judith and Charlie's crazy neighbor Rose, who wants to be a part of his life and is willing to do anything to be around. After the death of his brother, Alan Harper meets and befriends a lonely young man named Walden Schmidt who turns out to be a billionaire. Unable to afford his brother's home, Alan sells Walden the house, and as a way of showing his gratitude, Walden allows Alan and his son Jake to move in with him.