After escaping from jail, a teenage prostitute and a 16-year-old serial killer both go on a destructive road trip to Mexico. Though initially the complete antithesis of one another, their risky behaviors bring them closer together than they ever could have imagined.

Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.