Two bikers head from L.A. to New Orleans through the open country and desert lands, and along the way they meet a man who bridges a counter-culture gap of which they had been unaware.

An obsessed pathologist discovers and captures a parasitic creature that grows when fear grips its host.

Journalist Anne Roland explores the disturbing links behind her friend's sudden disappearance, an ominous government research chemical, and a disturbing radio broadcast of unknown origin.

Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.