The stars are gone. The planets have disappeared. Only individuals aboard space stations or starships were left to give the end a name -- The Quiet Rapture. After decades of decay and crumbling infrastructure, the Consolidation of Iron has made a discovery on a barren moon designated AT-5. An ocean of blood. Hoping to discover desperately needed resources they immediately launch an expedition. A submarine is crafted and a convict is welded inside. Due to the pressure and depth of the ocean the forward viewport has been encased in metal. If successful, they will earn their freedom. If not, another will follow. This will be the 13th expedition.

When Ripley's lifepod is found by a salvage crew over 50 years later, she finds that terra-formers are on the very planet they found the alien species. When the company sends a family of colonists out to investigate her story—all contact is lost with the planet and colonists. They enlist Ripley and the colonial marines to return and search for answers.

After a space merchant vessel receives an unknown transmission as a distress call, one of the crew is attacked by a mysterious life form and they soon realize that its life cycle has merely begun.