In the harsh, yet beautiful Australian outback lives a beast, an animal of staggering size, with a ruthless, driving need for blood and destruction. It cares for none, defends its territory with brutal force, and kills with a raw, animalistic savagery unlike any have seen before. Now coming face to face with the giant bloodthirsty killing machine, teens on a hiking trip will have the beast in order to en its reign of terror.

Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.