When a young doctor suspects she may not be alone in her new Brooklyn loft, she learns that her landlord has formed a frightening obsession with her.

Frances Mayes, a 35-year-old San Francisco writer, gets a divorce that leaves her with terminal writer's block and depression. Later, she decides to buy a house in Tuscany in order to change her life.

Lionel, a Mama's boy has the unwanted honor of having to look after his overbearingly evil mother. He ends up falling in love with a local woman who believes that they're destined together. In a moment of intentional sabotage of one of their dates, his mother is bitten by a mysterious creature that ends up zombifying her. It's only a matter of time before she rises from the dead a powerful, bloodthirsty zombie. It's only a matter of time before she starts infecting residents of the town and Lionel has to stop her...and them.