Eighteenth-century Spanish Jesuits try to protect a remote South American tribe in danger of falling under the rule of pro-slavery Portugal.

Four unfortunate men from different parts of the globe agree to risk their lives transporting gallons of nitroglycerin across dangerous Latin American jungle.

In 2002, Bolivian politician Pedro Gallo hires American James Carville's political consulting firm, Greenberg Carville Shrum, to help him win the 2002 Bolivian presidential election. GCS brings in Jane Bodine to manage the campaign in Bolivia. Battling her arch nemesis, the opposition's political consultant Pat Candy, Bodine successfully uses American political campaign strategies to lead Gallo to victory against Victor Rivera.

In New York, the college student Justine joins a group of activists led by Alejandro and he invites her to travel to Peru to protest against a timber industry that is destroying the Amazon rain forest. The group uses their cellphones to film the destruction and send the footages through Internet. Alejandro uses Justine that is almost killed by one security guard to succeed in his intent of calling attention of audiences. When the group is returning to civilization, the plane blows-up and crashes into the forest. Soon the survivors discover that they are not alone and they are abduct by a tribe of Indians. But their nightmare becomes worse when they realize that the Indians are cannibals.