Two middle-aged men embark on a spiritual journey through Californian wine country. One is an unpublished novelist suffering from depression, and the other is only days away from walking down the aisle.

A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.

A wealthy writer, who has had terrible experiences with money-hungry girlfriends and ex-wives, pretends to be a broke, washed-up novelist, to see if the woman he loves wants him for himself, or just for his money.

When CIA analyst Jack Ryan interferes with an IRA assassination, a renegade faction targets him and his family for revenge.

When a young woman becomes afflicted by stigmata, a priest is sent to investigate her case, which may have severe ramifications for his faith and for the Catholic Church itself.

A trio of sisters bond over their ambivalence toward the approaching death of their curmudgeonly father, to whom none of them was particularly close.