Harvard symbologist Robert Langdon works with a nuclear physicist to solve a murder and prevent a terrorist act against the Vatican during one of the significant events within the church.

Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.

A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.

Retired from active duty to train new IMF agents, Ethan Hunt is called back into action to confront sadistic arms dealer, Owen Davian. Hunt must try to protect his girlfriend while working with his new team to complete the mission.