A worldly ambitious monsignor clashes with his older brother, a cynical Los Angeles homicide detective who is investigating the brutal murder of a young prostitute.

An expectant couple who moves into the most haunted house in New Orleans call upon the services of the Vatican's elite exorcism team to save them from a demonic baby.

A long-divorced couple fakes being married as their family unites for a wedding.

Though a childhood bout with polio left him dependent on an iron lung, Mark O'Brien maintains a career as a journalist and poet. A writing assignment dealing with sex and the disabled piques Mark's curiosity, and he decides to investigate the possibility of experiencing sex himself. When his overtures toward a caregiver scare her away, he books an appointment with sex surrogate Cheryl Cohen-Greene to lose his virginity.

The story revolves around a Basque Roman Catholic priest dedicated to committing as many sins as possible, a death metal salesman from Carabanchel, and the Italian host of a TV show on the occult. These go on a literal "trip" through Christmas-time Madrid to hunt for and prevent the reincarnation of the Antichrist.