It's 1969 at a strict English girls' school where charismatic Abbie and intense and troubled Lydia are best friends. After a tragedy occurs at the school, a mysterious fainting epidemic breaks out threatening the stability of all involved.

Best friends and their daughters vacation in Rio de Janeiro only for one to fall for the other's daughter.

Though a childhood bout with polio left him dependent on an iron lung, Mark O'Brien maintains a career as a journalist and poet. A writing assignment dealing with sex and the disabled piques Mark's curiosity, and he decides to investigate the possibility of experiencing sex himself. When his overtures toward a caregiver scare her away, he books an appointment with sex surrogate Cheryl Cohen-Greene to lose his virginity.

Sylvia Stickles runs a convenience store with her husband and mother-in-law. One day, Sylvia is hit on the head and transforms from an uptight prude to a sex-crazed lunatic. As she goes on a rampage through town, Sylvia attracts the attention of Ray Ray, a sexual healer and tow truck driver in search of the world's greatest orgasm. Their sexual revolution, however, causes a class war in their tiny Baltimore community.