While stuck at a wedding in Palm Springs, Nyles (Andy Samberg) meets Sarah (Cristin Milioti), the maid of honor and family black sheep. After he rescues her from a disastrous toast, Sarah becomes drawn to Nyles and his offbeat nihilism. But when their impromptu tryst is thwarted by a surreal interruption, Sarah must join Nyles in embracing the idea that nothing really matters, and they begin wreaking spirited havoc on the wedding celebration.

Robin Monroe, a New York magazine editor, and the gruff pilot Quinn Harris must put aside their mutual dislike if they are to survive after crash landing on a deserted South Seas island.

An average aquarium cleaner house-sits for a gigolo, only to be forced to become one himself.