Inspired by the fictional Dr. Heiter, disturbed loner Martin dreams of creating a 12-person centipede and sets out to realize his sick fantasy.

Bully prison warden Bill Boss, leading a big state prison in the US of A, has a lot of problems; his prison statistically has the highest amount of prison riots, medical costs and staff turnover in the country. But foremost he is unable to get the respect he thinks he deserves from his inmates and the state Governor. He constantly fails in experimenting with different ideas for the ideal punishment to get the inmates in line, which drives him, together with the sizzling heat, completely insane. Under threats of termination by the Governor, his loyal right hand man Dwight comes up with a brilliant idea. A revolutionary idea which could change the American prison system for good and save billions of dollars. An idea based on the notorious Human Centipede movies, that will literally and figuratively get the inmates on their knees, creating the ultimate punishment and deterrent for anyone considering a life of crime. Having nothing to lose, Bill and Dwight create a jaw-dropping 500-person...

Two pretty but ditsy American girls are on a road trip through Europe. In Germany, they end up alone at night with a broken car in the woods. They search for help and find an isolated villa. The next day, they awaken to find themselves trapped in a terrifying makeshift basement hospital along with a Japanese man. An older German man identifies himself as a retired surgeon specialized in separating Siamese twins. However, his three "patients" are not about to be separated but joined together in a horrific operation. He plans to be the first person to connect people via their gastric systems. By doing so, he plans to bring to life his sick lifetime fantasy, the human centipede.