Inspired by the fictional Dr. Heiter, disturbed loner Martin dreams of creating a 12-person centipede and sets out to realize his sick fantasy.

Martin is a mentally disturbed loner who lives with his mother in a bleak housing project. He works the night shift as a security guard in an equally grim and foreboding underground parking complex. To escape his dreary existence, Martin loses himself in the fantasy world of the cult horror film Ludzka stonoga (2009), fetishizing the meticulous surgical skills of the gifted Dr. Heiter, whose knowledge of the human gastrointestinal system inspires Martin to attempt the unthinkable.

Two pretty but ditsy American girls are on a road trip through Europe. In Germany, they end up alone at night with a broken car in the woods. They search for help and find an isolated villa. The next day, they awaken to find themselves trapped in a terrifying makeshift basement hospital along with a Japanese man. An older German man identifies himself as a retired surgeon specialized in separating Siamese twins. However, his three "patients" are not about to be separated but joined together in a horrific operation. He plans to be the first person to connect people via their gastric systems. By doing so, he plans to bring to life his sick lifetime fantasy, the human centipede.