Heroes is a cult serial saga about people all over the world discovering that they have superpowers and trying to deal with how this change affects their lives. Not only are they discovering what having superpowers means to them but also the larger picture of where those powers come from and what they might mean to the rest of the world.

When over-achieving medical resident Liv Moore attends a party that turns into a zombie feeding frenzy, she ends up joining the ranks of the living dead. Determined to pass as human despite her pale appearance and newly listless demeanor, Liv forms a plan to resist her drive to consume fresh human brains by taking a job at a coroner's office, where she can secretly snack on the brains of corpses delivered there. Soon discovering that she absorbs the memories of those she feeds on, she finds new purpose by posing as a psychic and working with a detective to help solve their murders.

Sydney Bristow, an agent who has been tricked to believe she is working for the U.S. government, is actually working for a criminal organization named the Alliance of Twelve. Upon learning this, Sydney becomes a double agent for the real CIA.