The 4077th Mobile Army Surgical Hospital is stuck in the middle of the Korean war. With little help from the circumstances they find themselves in, they are forced to make their own fun. Fond of practical jokes and revenge, the doctors, nurses, administrators, and soldiers often find ways of making wartime life bearable.

The "two guys" are Berg and Pete who share an apartment and support themselves by delivering pizza from Beacon Street Pizza run by Bill. In the first years of medical school, Berg had a cavalier approach to life and women but now finds himself with Ashley, a fellow med student. Berg is generally happy about this relationship, but it has its ups and downs - that's what makes it so much fun. Pete has abandoned his plans to become an architect and is searching for a career Sharon is "the girl" - the upstairs neighbor who hates being a chemical saleswoman although she can't complain about the benefits, including a hefty salary and a shining "Beemer." Sharon's boyfriend Johnny adores her, but she's not sure what she wants... maybe it's because she's already met the ideal man but doesn't know it. For now, she enjoys being part of a special threesome enjoying life no matter how unbelievable it can really be.

Johnny had the perfect life until he was in coma for six years. When he awoke, he found his fiancee married to another man. His son doesn't know him. Everything's changed, including Johnny. With one touch, he can see things.

This saga chronicles a nation divided and two families,the Hazards of Pennsylvania and the Mains of South Carolina,caught on opposite sides when the Civil War erupts in May 1861. As war is raged on one battlefield after another, lives on the home front drastically change. The hatred, prejudice and greed that tear the fabric of a nation, also threatens the very foundation of love and friendship between these two families.