After being double-crossed and left for dead, a mysterious man named Walker single-mindedly tries to retrieve the money that was stolen from him.

A mild-mannered chemist and an ex-con must lead the counterstrike when a rogue group of military men, led by a renegade general, threaten a nerve gas attack from Alcatraz against San Francisco.

In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.

San Francisco Bay, January 18, 1960. Frank Lee Morris is transferred to Alcatraz, a maximum security prison located on a rocky island. Although no one has ever managed to escape from there, Frank and other inmates begin to carefully prepare an escape plan.