Dr. Richard Kimble, unjustly accused of murdering his wife, must find the real killer while being the target of a nationwide manhunt led by a seasoned U.S. Marshal.

A government fakes the death of a criminal to turn this young woman into a killer on its service.

Fifteen years after the original film, the philosophical Lieutenant William F. Kinderman is investigating a baffling series of murders on Georgetown that all contain the hallmarks of The Gemini, a deceased serial killer. His investigation eventually leads him to a catatonic patient in a psychiatric hospital who has recently started to speak, claiming he is The Gemini and detailing the murders, but bears a striking resemblance to Father Damien Karras.