Lance Preston and the crew of "Grave Encounters", a ghost-hunting reality television show, are shooting an episode inside the abandoned Collingwood Psychiatric Hospital, where unexplained phenomena have been reported for years. All in the name of good television, they voluntarily lock themselves inside the building for the night and begin a paranormal investigation, capturing everything on camera. They quickly realize that the building is more than just haunted - it is alive - and it has no intention of ever letting them leave. They find themselves lost in a labyrinth maze of endless hallways and corridors, terrorized by the ghosts of the former patients. They soon begin to question their own sanity, slipping deeper and deeper into the depths of madness, ultimately discovering the truth behind the hospital's dark past...and taping what turns out to be their final episode.

Directionless teenager Susanna is rushed to Claymoore, a mental institution, after a supposed suicide attempt. There she befriends a group of troubled women who deeply influence her life.

A psychiatrist awakens as a patient in a mental institution, with no memory of the murder she's accused of committing. As she tries to regain her memory, a vengeful spirit manipulates her.

Three friends plan to pull off a simple robbery and go on the run.

Security guard David Dunn uses his supernatural abilities to track Kevin Wendell Crumb, a disturbed man who has twenty-four personalities.

Fifteen years after the original film, the philosophical Lieutenant William F. Kinderman is investigating a baffling series of murders on Georgetown that all contain the hallmarks of The Gemini, a deceased serial killer. His investigation eventually leads him to a catatonic patient in a psychiatric hospital who has recently started to speak, claiming he is The Gemini and detailing the murders, but bears a striking resemblance to Father Damien Karras.