Two decades after surviving a massacre on October 31, 1978, former baby sitter Laurie Strode finds herself hunted by persistent knife-wielder Michael Myers. Laurie now lives in Northern California under an assumed name, where she works as the headmistress of a private school. But it's not far enough to escape Myers, who soon discovers her whereabouts. As Halloween descends upon Laurie's peaceful community, a feeling of dread weighs upon her -- with good reason.

Six years ago, Michael Myers terrorized the town of Haddonfield, Illinois. He and his niece, Jamie Lloyd, have disappeared. Jamie was kidnapped by a bunch of evil druids who protect Michael Myers. And now, six years later, Jamie has escaped after giving birth to Michael's child. She runs to Haddonfield to get Dr. Loomis to help her again.

One year after the events of Halloween 4: The Return of Michael Myers (1988), the Shape returns to Haddonfield once again in an attempt to kill his now-mute niece.

When police officer Carter (Aaron Poole) discovers a blood-soaked man limping down a deserted road, he rushes him to a local hospital with a barebones, night shift staff. As cloaked, cult-like figures surround the building, the patients and staff inside start to turn ravenously insane. Trying to protect the survivors, Carter leads them into the depths of the hospital where they discover a gateway to immense evil.