In the late 1960s, just for a lark, graduate student Eddie Jessup, known for being unconventional, brilliant and slightly mad, conducts experiments with an isolation chamber, using himself as the subject. His experiences in the chamber cause him to hallucinate, much of the imagery being religious-based although he's not religious. Seven years later, he is a respected full professor in the Harvard Medical School. Believing he has lost his edge and fallen into an unwanted state of respectability, Eddie decides to resume his work with sensory deprivation, this time using hallucinogens, specifically untested ones used in mystical Mexican rituals, to enhance the isolation-take experience. After initial tests, he claims he entered an alternate physical and mental state. Although unbelieving of Eddie's claims, his colleagues Arthur Rosenberg and Mason Parrish, as well as Eddie's wife Emily, herself a respected academic, are concerned for Eddie's well being. However, if Eddie's claims are indeed true, he could do irreparable harm to himself and others around him, especially if his altered states are uncontrollable.

Two death-obsessed sisters, outcasts in their suburban neighborhood, must deal with the tragic consequences when one of them is bitten by a deadly werewolf.

Violence ensues after an extraterrestrial race forced to live in slum-like conditions on Earth finds a kindred spirit in a government agent exposed to their biotechnology.

An actress’s perception of reality becomes increasingly distorted as she finds herself falling for her co-star in a remake of an unfinished Polish production that was supposedly cursed.

An actress’s perception of reality becomes increasingly distorted as she finds herself falling for her co-star in a remake of an unfinished Polish production that was supposedly cursed.

A young man inadvertently breaks three important rules concerning his new pet and unleashes a horde of malevolently mischievous monsters on a small town.

As an actress begins to adopt the persona of her character in a film, her world becomes nightmarish and surreal.

After being rescued and brought to an island, a man discovers that its inhabitants are experimental animals being turned into strange-looking humans, all of it the work of a visionary doctor.