In the late 1960s, just for a lark, graduate student Eddie Jessup, known for being unconventional, brilliant and slightly mad, conducts experiments with an isolation chamber, using himself as the subject. His experiences in the chamber cause him to hallucinate, much of the imagery being religious-based although he's not religious. Seven years later, he is a respected full professor in the Harvard Medical School. Believing he has lost his edge and fallen into an unwanted state of respectability, Eddie decides to resume his work with sensory deprivation, this time using hallucinogens, specifically untested ones used in mystical Mexican rituals, to enhance the isolation-take experience. After initial tests, he claims he entered an alternate physical and mental state. Although unbelieving of Eddie's claims, his colleagues Arthur Rosenberg and Mason Parrish, as well as Eddie's wife Emily, herself a respected academic, are concerned for Eddie's well being. However, if Eddie's claims are indeed true, he could do irreparable harm to himself and others around him, especially if his altered states are uncontrollable.

With the assistance of the Enterprise crew, Admiral Kirk must stop an old nemesis, Khan Noonien Singh, from using the life-generating Genesis Device as the ultimate weapon.

After being rescued and brought to an island, a man discovers that its inhabitants are experimental animals being turned into strange-looking humans, all of it the work of a visionary doctor.

Violence ensues after an extraterrestrial race forced to live in slum-like conditions on Earth finds a kindred spirit in a government agent exposed to their biotechnology.

Young Blade Runner K's discovery of a long-buried secret leads him to track down former Blade Runner Rick Deckard, who's been missing for thirty years.