In the late 1960s, just for a lark, graduate student Eddie Jessup, known for being unconventional, brilliant and slightly mad, conducts experiments with an isolation chamber, using himself as the subject. His experiences in the chamber cause him to hallucinate, much of the imagery being religious-based although he's not religious. Seven years later, he is a respected full professor in the Harvard Medical School. Believing he has lost his edge and fallen into an unwanted state of respectability, Eddie decides to resume his work with sensory deprivation, this time using hallucinogens, specifically untested ones used in mystical Mexican rituals, to enhance the isolation-take experience. After initial tests, he claims he entered an alternate physical and mental state. Although unbelieving of Eddie's claims, his colleagues Arthur Rosenberg and Mason Parrish, as well as Eddie's wife Emily, herself a respected academic, are concerned for Eddie's well being. However, if Eddie's claims are indeed true, he could do irreparable harm to himself and others around him, especially if his altered states are uncontrollable.

Billy is mute, but it hasn't kept her from becoming a successful makeup artist. While in Russia, working on a film directed by her sister's boyfriend, Andy, Billy finds herself trapped in the studio one night and is horrified to see a snuff film being made. Billy escapes and, with the help of her sister, Kate, alerts authorities about what she saw. Unfortunately, in doing so, she makes an enemy of the Russian mafia, who funded the snuff film.

A teenage girl sets out to give a nebbish classmate the ultimate high school makeover. An updated remake of the 1999 film, 'She's All That'.

An FBI agent and Florida State officer team up to investigate a string of unsolved murder cases.

An ordinary teenage boy discovers his family is part of a gruesome orgy cult for the social elite.

A psycho-physiologist experiments with drugs and a sensory-deprivation tank and has visions he believes are genetic memories.

Four horror and science fiction segments, directed by four famous directors, each of them being a new version of a classic story from Rod Serling's landmark television series.